RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Smad7
RNA ID
RNA Type
mRNA
Alteration Pattern
histone deacetylation
Species
rattus norvegicus
Detection Methods
Masson's trichrome staining; Immunohistochemistry; Immunofluorescence etc.
Target
NA
Pathway
NA
PubMed ID
Title
Suberoylanilide hydroxamic acid attenuates paraquat-induced pulmonary fibrosis by preventing Smad7 from deacetylation in rats
Year
2016
Function
"SAHA (histone deacetylase inhibitor, HDACi) suppressed PQ-induced lung fibrosis in rats by stabilizing Smad7 level via preventing Smad7 from deacetylation, thus attenuating Smad3 activity, resulting in the inhibition of fibroblast differentiation and collagen expression."